WhatsApp Print Email Facebook Twitter Linkedin Advertisement FOR centuries, the pomegranate has been recognised as a super fruit, containing A, B, and C vitamins as well as being rich in antioxidants but for the last six years the Nachmias family, have been producing the only pure 100 per cent pomegranate wine in the world!Rimon is the exclusive producer of the world’s only 100 per cent pure pomegranate wine. Since 2003, father and son, Gaby and Avi Nachmias have been producing a unique pomegranate wine from their orchard located on a mountain in Upper Galilee, Israel.Sign up for the weekly Limerick Post newsletter Sign Up Cultivated a “super fruit” that is sweeter, deeper in colour, and richer in vitamins and antioxidants than other pomegranate varieties, the end result is famous for its high juice content, soft tannins, sweetness and rich flavours.The health-giving properties of the fruit are also still contained in this unique wine, it has three times the antioxidant power of normal red wine or green tea, as well as a wealth of vitamins and minerals.All Rimon wines witch include a dry, dessert and port style pomegranate wines are produced according to the highest quality winemaking standards and all are certified Kosher.At present they are only available at Waitrose stores in the UK, but Irish customers can buy from the website on www.rimonwinery.co.uk NewsPomegranate wine, is this a super wine from the super fruit?By admin – August 27, 2009 936 Previous articleCAO points surge signals career preferencesNext articleMy perfect market pesto admin
View post tag: Navy More than 150 Sailors participated in a wreath laying ceremony on the USS Arizona Memorial June 4 to commemorate the 71st anniversary of the Battle of Midway. The Battle of Midway, considered the turning point of the Pacific during World War II, was fought over a period of three days starting June 4, 1942 when U.S. Navy strike forces prevented the Japanese from taking control of the Midway Islands.“The war started with the attack on Pearl Harbor and the sinking of USS Arizona and ended when the surrender documents were signed on the deck of USS Missouri in Tokyo Bay,” said Rear Admiral Frank Ponds, Commander of Navy Region Hawaii and Naval Surface Group Middle Pacific. “To me Missouri and Arizona are symbols of the triumph that is the American fighting spirit. The spirit that was able to overcome our heavy losses at Pearl Harbor and then gain victory from superior forces at the Battle of Midway.”The event focused on the historical importance of the Battle of Midway, which occurred nearly six months after the attack on Pearl Harbor.A relatively small fleet of U.S. forces defended against and defeated four carriers of the Japanese navy during the Battle of Midway, which resulted in one of the most significant losses in Japanese naval history.The keynote speaker for the ceremony was retired Navy Admiral Thomas Fargo, who previously served as Commander in Chief of the U.S. Pacific Fleet during the time the Midway Atoll was designated as the “Battle of Midway National Memorial.”“The success at the Battle of Midway was an emotional lift and a momentum shift, a morale boost that finally demonstrated that the American forces had what it took to indisputably win the war in the Pacific” said Fargo. “The legacy of our Midway veterans is embodied in the men and women who serve in our Armed Forces today.”Chief Logistics Specialist Ebony Pinnock marked the conclusion of the ceremony explaining what the significance of the traditional wreath laying.“This wreath, and the wreaths being presented around the world, is in honor of our Midway veterans,” said Pinnock. “We took a moment to remember and honor the spirit of the Midway victory in our Navy and our nation, we pause to honor all those who have served and continued to serve with honor, courage and commitment.”For some of the attending Sailors, this was their first experience aboard the USS Arizona Memorial.“I felt invigorated, I was trying not to cry,” said Seaman Colton Yount, assigned to USS Reuben James (FFG 57). “This was my first time being a part of a ceremony like that. To actually be there and to witness something like that it actually made me feel kind of proud to be a part of the Navy and this country and know I’m also playing a role in defending my country just like the people at the Battle of Midway.”[mappress]Press Release, June 6, 2013 Back to overview,Home naval-today Hawaii Sailors Commemorate Battle of Midway View post tag: Battle View post tag: Naval Training & Education View post tag: News by topic View post tag: Defence View post tag: Defense View post tag: Hawaii View post tag: Midway Share this article Hawaii Sailors Commemorate Battle of Midway June 6, 2013 View post tag: sailors View post tag: Commemorate
Harvard Stem Cell Institute (HSCI) researchers have identified a compound that helps protect the cells destroyed by spinal muscular atrophy (SMA), the most frequent fatal genetic disease in children under 2 years of age.SMA is a neurodegenerative disease targeting motor neurons, the long nerve cells that relay messages from the brain to the muscles and that are, consequently, responsible for bodily movements, including walking, swallowing, and even breathing. Patients with milder forms of SMA experience muscle wasting that may confine them to a wheelchair, while the more severe forms cause paralysis and death before the second birthday.About one in 50 people are genetic carriers of the disease.Because of a dysfunctional gene, many motor neurons in SMA patients are unable to produce adequate amounts of a protein called survival of motor neuron (SMN). The deficiency causes cellular stress and eventually cell death. Rather than fixing the gene, which has been the strategy of many labs looking to develop SMA therapies, the Harvard team has identified a compound that helps stabilize the SMN protein both in human neurons in a dish and in mouse models.The findings were published in the journal Cell Reports.“This discovery opens up new lines of drug interrogation,” said Lee Rubin, HSCI principal faculty member and the senior author on the study. Rubin’s lab, which operates out of in Harvard’s Department of Stem Cell and Regenerative Biology, uses induced pluripotent stem cells (iPS cells) to make human models of neurological diseases.In 2015, Rubin made a variety of neuronal types from the iPS cells of SMA patients in order to determine why motor neurons in particular were targeted, and found they experienced a fatal stress response similar to motor neurons affected by amyotrophic lateral sclerosis (ALS), the late-onset neurodegenerative disease more commonly known as Lou Gehrig’s disease.Additionally, some SMA-affected motor neurons were dying before others, though all of the neurons had the same genetic mutations and were experiencing the same stressful environment.“Clearly, some motor neurons were surviving, so the next question was whether this is random or if there is a molecular explanation,” Rubin said.Early on in their most recent study, the researchers found that within a single petri dish of motor neurons derived from an SMA patient, some produced up to four times as much SMN protein as their neighbors. Over time, those motor neurons with higher levels of SMN were more likely to survive after exposure to toxic environments and stressors.When the team analyzed motor neurons derived from ALS patients, they found similar results: Motor neurons with higher levels of SMN were likelier to survive than those with lower levels.“The surprise was when we looked in a control culture and also saw differences between the individual neurons,” Rubin said.“It is clear that the SMN protein is necessary for all motor neuron survival, not just motor neurons targeted by ALS or SMA,” said Natalia Rodríguez-Muela, a postdoctoral fellow in Rubin’s lab and co-first author on the paper. The results suggest that if the team could increase the amount of SMN protein in any single motor neuron, they would be able to rescue the cell.During a cell’s life span, proteins are constantly being made and degraded, made and degraded again. To interrupt the process of breaking down the SMN protein, the researchers looked at a family of proteins called Cullins, which act as a part of the cell machinery that regulates protein degradation.In 2011, the Rubin lab had determined that an enzyme called GSK3b helps control SMN stability. Nearly all proteins degraded by GSK3b are flagged for degradation by a pathway that involves a specific member of the Cullin family. Rubin said the researchers hypothesized that if they could block that Cullin-mediated process, the SMN proteins would not be flagged for degradation and would remain stable longer.The researchers, led by co-first author Nadia Litterman, then dosed human and murine motor neurons with a compound known to block the specific Cullin and found that exposure to the compound made SMN proteins more stable and more abundant. As a consequence, the compound promoted survival of all motor neurons, both in human cells in the dish and in mouse models.Additionally, mice with SMA, even the more severe forms of the disease, had some of their symptoms improve after exposure to the compound.“This process points to an unexplored therapeutic direction that could benefit patients of not one, but two separate diseases,” Rubin said.Harvard’s Office of Technology Development has filed a patent application on the approach.This work was supported by the SMA Foundation, National Institute of Neurological Disorders and Stroke grant P01 NS066888, National Institutes of Health grants NS045523 and NS075672, Massachusetts Spinal Cord Injury Research Trust, and the Harvard Stem Cell Institute.
Editor’s note: This is today’s edition of the Inside the Dodgers newsletter by J.P. Hoornstra. To receive the newsletter in your inbox, sign up here.Cross another potential free agent off your 2020-21 wish list. With all due respect to Mookie Betts, who stands alone as the crown jewel of that winter’s free agent crop, Mike Trout is not just another potential free agent. He was the man that had Bryce Harper lobbying (tampering?) him to come to Philadelphia on a local radio station. He’s the best player in baseball. Now, he’s also the best-paid player in baseball, under the terms of a 12-year, $426.5 million extension soon to be finalized with the Angels.This shouldn’t mean as much as it does. The Dodgers have conspicuously de-emphasized free agent splurges in recent years. They still spend, but the most they’ve handed out to individual players were all re-signs: Clayton Kershaw (three years, $93 million last November), Kenley Jansen (five years, $80 million in 2017) and Justin Turner (four years, $64 million in 2017). Would they have shelled out more than $360 million to pry Trout out of Anaheim? Probably not.Agreeing to a lifetime contract extension like Trout’s isn’t a personal affront to any of the other 29 teams. This is just what elite players do now. They look around at what over-30 free agents are making on the open market, then chase all the guaranteed years and dollars they can find. I half-joked on Twitter that drafting, developing and signing future Hall of Famers to long-term extensions is the new market inefficiency. It’s kind of true. It’s getting less reasonable to expect players of Trout’s caliber to reach free agency every year. The inevitable has happened – Dave Roberts confirmed that Clayton Kershaw will start the season on the injured list.Enemy territory – The Giants’ scouting director was “baptized in Dodger blue.”It’s time for Dodger baseball – Artist Harmony Deimling painted Vin Scully.It’s a hookah-smoking llama – Minor League Baseball is bringing back la Copa de Diversion. 2022: Aaron Judge, Trea Turner, Gary Sanchez, Blake Snell, Aaron Nola (club option), Luis Severino (club option), Noah Syndergaard, Edwin Diaz.-J.P.Thanks for reading today’s Inside the Dodgers newsletter. Get in in your inbox by signing up here. Finding stars from within the organization seems to be the Dodgers’ strategy anyway. To that end, here are the years that matter: Corey Seager becomes a free agent in 2021, Cody Bellinger and Julio Urías in 2023. Circle those dates on your hypothetical calendar. Joc Pederson (2020), Kiké Hernandez (2020), Chris Taylor (2021) and Ross Stripling (2022) might be extension candidates at some point, too. Not the kind of long-term, Trout-esque extensions that break records, but extensions nonetheless.Let’s do this thought exercise anyway. Knowing they might never reach the market, and the Dodgers might never pony up to sign them, here are the names of select free agents and when you can covet them in public without being accused of tampering:2019: Paul Goldschmidt, Gerrit Cole, Chris Sale, Yasmani Grandal, Anthony Rendon, Jose Abreu, Xander Bogaerts, Scooter Gennett and Nicholas Castellanos. Stephen Strasburg has a player opt-out.2020: Betts, Jacob deGrom, J.T. Realmuto, George Springer, Trevor Bauer, Andrelton Simmons, James Paxton, Blake Treinen, Robbie Ray. Giancarlo Stanton has an opt-out.2021: Kris Bryant, Freddie Freeman, Francisco Lindor, Carlos Correa, Anthony Rizzo, Michael Conforto, Salvador Perez, Trevor Story, Aroldis Chapman, Javier Baez. Newsroom GuidelinesNews TipsContact UsReport an Error Cloning while they’re multiplying.
DETROIT (AP)—Shannon Eastin used her left hand to tuck her pony tail under her cap after the national anthem and got ready for work.She seemed to do her job, which ended by helping to separate St. Louis Rams and Detroit Lions players after some shoving, pushing and shouting broke out following the final play. Eastin became the first woman to be an official in an NFL regular-season game, working as the line judge in the Rams-Lions matchup Sunday.“It’s a great milestone,” Detroit coach Jim Schwartz said after his team beat St. Louis 27-23. “But we didn’t think about it all during the game.”That’s probably just the way she—and the league—liked it.Eastin is among the replacement officials hired by the league while the regular officials are locked out. Replacement officials are working games for the first time in 11 years.She became the first female official to work an NFL preseason game last month as the line judge when Green Bay played at San Diego. The Pro Football Hall of Fame has the hat and whistle she used during that preseason game, and they are expected to be displayed in Canton, Ohio.The 42-year-old resident of Tempe, Ariz. has worked as a referee in the Mid-Eastern Athletic Conference—college football’s second-highest level—and has 16 years of officiating experience.NFL Commissioner Roger Goodell has said having Eastin on the field is a great opportunity for her and the league.“She’s well prepared for it, and I think she’ll do terrific,” Goodell said last month. “So we’re excited about that.“And there are more coming, by the way. We’ve been working along this path to try to properly train and prepare a female official, and now we have the opportunity.”Pittsburgh Steelers linebacker Larry Foote believes it is good for the game to have female officials, even though he worries about her safety working alongside some of the world’s biggest, strongest and fastest athletes.“Women are more honest and fair than men and they know how to catch a man cheating,” Foote said. “I hope she’s just a line judge. Don’t want her to get hurt.”Eastin, who is originally from Worcester, Mass., started officiating high school games before moving up to colleges. She owns a company called SE Sports Officiating, which trains officials in football and basketball.“I’ll be working even harder, to show I am capable and I am where I should be,” Eastin has said.She is joining a small group of women to break into officiating ranks at the highest levels of sports. Violet Palmer, one of Eastin’s inspirations, started officiating NBA games in 1997 and is still in the league.Kathy Babiak, co-director of SHARP, a partnership between the Women’s Sports Foundation and the University of Michigan, said Eastin’s accomplishment is encouraging.“It shows the strides women and girls in sports have been making since Title IX was passed 40 years ago,” Babiak said. “Before Title IX, these kinds of opportunities for women and girls were not even imaginable. It shows that women and girls have a desire, interest and ability to work in sports at all levels—even men’s professional sports.“Some girl will be watching Sunday and say, ‘Hey, I want to do the same thing!’”